Immunology - Cytokines

Cytokine

⇒ Endocrine, Paracrine, Autocrine

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❗ IL-1 family: IL-⍺, IL-β

Hematopoietin (class I cytokine) family

IFN(class II cytokine) family

TNF family

IL-17 family

Chemokine family

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IL-1 family

early DC,monocytes,MØ에서 분비; viral,parasite,bacterial Ag가 자극, 
pro-inflammatory, systemic 
⇒ **caspase 1 enzyme activation ⇒ inflammasome**

pro-IL-1⍺(막단백질)/pro-IL-1β(soluble): caspase 1 에 의해 trimming, activation

IL-18/IL-33 ⇒ caspase 1에 의해 process

IL-1RI, IL-1RAcP가 dimer를 이루어 receptor로 작용

Hematopoietin (Class I) family

혈소판 분화, histamin 분비

IL-2, IL-4, IL-3, IL-6, IL-12 | IL-2R𝛼/𝛽/𝛾

IFN

Type I IFN | IFN-R(막 단백질)

PRR에 의해 분비 촉진

IFN⍺,IFNβ(MØ, DC, 감염세포에서 분비) dimer

Type II IFN (IFN𝛾)

T/NK cell 에서 분비 TH cell로 하여금 MØ activation inducing

TNF

MØ, lymphocytes, fibroblast, kertinocytes에 의해 분비, 
pro-inflammatory, response to infection, inflammation

TNF-R1, TNF-R2 → FasL → Fas → FADD → caspase-8 → apoptisis

IL-17 family

IL-17A(TC activation) / IL-17B / IL-17C / IL-17D / IL-17E

NF-κB activation
Activation of MAP kinase pathway and cytokine mRNA stabilization
Activation of transcription factors C/EBPβ and C/EBPδ

Chemokine

chemokine mediated signal by GPCR
chemotaxis
chemoattractants