Create a simple XLSX file

import xlsxwriter

# Create a workbook and add a worksheet
workbook = xlsxwriter.Workbook('Expenses01.xlsx')
worksheet = workbook.add_worksheet()

# Some data we want to write to the worksheet
expenses = (
    ['Rent', 1000],
    ['Gas', 100],
    ['Food', 300],
    ['Gym', 50]
)

# Start from the first cell. Rows and columns are zero indexed
row = 0
col = 0

# Iterate over the data and write it out row by row
for item, cost in expenses:
    worksheet.write(row, col, item)
    worksheet.write(row, col + 1, cost)
    row += 1

# Write a total using a formula
worksheet.write(row, 0, 'Total')
worksheet.write(row, 1, '=SUM(B1:B4)')

workbook.close()

Note

# XlsxWriter can only create new files. It cannot read or modify existing files.
# Throughout XlsxWriter, rows and columns are zero indexed. The first cell in a worksheet, A1, is (0, 0).